With the increase of urbanization construction in mountainous areas in China, the problems of stability of high-filled slopes, foundation settlement and deformation induced by the hill cutting project are becoming more and more prominent. In this paper, the study on the deformation and stability assessment of the high-filled slope are performed comprehensively using the mechanical property test, finite element simulation, limit equilibrium analysis, and automatic construction monitoring in the Hejia Poverty-Alleviation Industrial Park in Yunxi County, Shiyan City, Hubei Province. The evaluation results show that the maximum settlement at the site during the time-step filling process appears in the surface area. The settlement pattern shows the maximum settlement is at the center and gradually decreasing with the increases with the backfill depth and horizontal distance, with a more obvious spatial influence range. The factor of safety is 2.531 after the backfill. The high-filled slope is in a safer state. However, considering the influence of the subsequent rainfall and the construction load, engineering measures should be applied consequently. The slope deformation was observed occurring mainly within 10 m below the ground surface by combining the long-term monitoring data of settlement and the inclination measurement. The results can provide technical and practical experience for the risk assessment, the geohazard prevention and the control of high-filled slopes in the hill cutting project.